Table 5. Distribution of VKORC1 variants by county.
County | N | No mutation (%) | Tyr139Cys | Leu120Gln | Tyr139Ser | Tyr139Cys, Leu120Gln | Tyr139Cys, Tyr139Ser | Tyr139Cys, Leu120Gln, Tyr139Ser |
---|---|---|---|---|---|---|---|---|
Berkshire | 25 | 3 (12.0) | 16 | 1 | 0 | 5 | 0 | 0 |
Cambridgeshire | 21 | 8 (38.1) | 13 | 0 | 0 | 0 | 0 | 0 |
Dorset | 7 | 3 (42.9) | 4 | 0 | 0 | 0 | 0 | 0 |
Gloucestershire | 3 | 0 (0.0) | 2 | 0 | 0 | 1 | 0 | 0 |
Greater London | 3 | 1 (33.3) | 2 | 0 | 0 | 0 | 0 | 0 |
Hampshire | 9 | 2 (22.2) | 1 | 1 | 0 | 4 | 0 | 1 |
Kent | 7 | 3 (42.9) | 4 | 0 | 0 | 0 | 0 | 0 |
Leicestershire | 35 | 19 (54.3) | 16 | 0 | 0 | 0 | 0 | 0 |
North Yorkshire | 24 | 13 (54.2) | 8 | 1 | 0 | 0 | 2 | 0 |
Oxfordshire | 10 | 2 (20.0) | 7 | 0 | 0 | 1 | 0 | 0 |
Powys | 2 | 1 (50.0) | 1 | 0 | 0 | 0 | 0 | 0 |
Shropshire | 4 | 0 (0.0) | 2 | 0 | 0 | 0 | 2 | 0 |
Sussex | 11 | 0 (0.0) | 8 | 1 | 0 | 2 | 0 | 0 |
Wiltshire | 18 | 5 (27.8) | 11 | 2 | 0 | 0 | 0 | 0 |
Worcestershire | 5 | 0 (0.0) | 5 | 0 | 0 | 0 | 0 | 0 |
Total | 184 | 60 (32.6) | 100 | 6 | 0 | 13 | 4 | 1 |