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. Author manuscript; available in PMC: 2016 Nov 14.
Published in final edited form as: J Mater Chem B. 2015 Sep 11;3(42):8314–8320. doi: 10.1039/C5TB01692D

Figure 6.

Figure 6

The cytotoxicity efficacy of DOX-loaded silk-vaterite microspheres on MDA-MB-231 cells cultured for 5 days: (a) CCK-8 assay of MDA-MB-231 cells under different DOX concentrations. The samples were as follows: DOX, free DOX; DOX/M-0, DOX-loaded M-0; DOX/M-300, DOX-loaded M-300; DOX/M-305, DOX-loaded M-305; DOX/M-310, DOX-loaded M-310; and CaCO3, various DOX-free silk-vaterite microspheres; (b–d) Confocal fluorescence images of MDA-MB-231 cells when cultured with DOX-loaded M-300 microspheres at DOX concentration of 10 µg/mL for 5 days. The blue stands for DAPI, the red stands for DOX. The images indicate that DOX released from DOX-loaded microspheres enter cells.