Table 1. Demographic features of patients with SCA.
SCA 1 (n = 52); P | SCA 2 (n = 64); P | SCA 3 (n = 117); P | SCA 6 (n = 68); P | P | |
---|---|---|---|---|---|
Gender (male), n (%) | 22 (42%); 0.47 | 29 (45%); 0.78 | 58 (50%); 0.45 | 32 (47%); 0.97 | 0.84 |
Race (white), n (%) | 49 (94%); <0.001 | 50 (78%); 0.41 | 62 (53%); <0.001 | 62 (91%); <0.001 | <0.001 |
Age, yr | 49.6 (12.5); 0.022 | 49.3 (13.0); 0.004 | 51.0 (11.5); 0.011 | 64.5 (10.8); <0.001 | <0.001 |
Age of onset, yr | 40.5 (11.3); 0.31 | 35.4 (11.4); <0.001 | 40.3 (11.4); 0.053 | 52.6 (9.9); <0.001 | <0.001 |
Disease duration, yr | 9.2 (7.1); 0.041 | 13.7 (8.5); 0.003 | 10.5 (7.2); 0.16 | 12.1 (9.9); 0.38 | 0.013 |
SARA score | 14.0 (8.6); 0.16 | 17.7 (7.2); 0.004 | 15.1 (8.9); 0.39 | 14.8 (7.4); 0.59 | 0.033 |
UHDRS | 17.8 (6.2); 0.28 | 17.1 (6.3); 0.77 | 16.4 (6.5); 0.23 | 17.2 (5.7); 0.90 | 0.60 |
Functional stage | 2.8 (1.3); 0.11 | 3.0 (1.2); 0.96 | 3.1 (1.3); 0.61 | 3.1 (1.3); 0.37 | 0.44 |
Values are reported as mean (SD); P value, unless otherwise noted. The P-value under each data point represents a comparison of that particular SCA against all other SCAs. These P-values were calculated with χ2 tests for categorical variables, t test for continuous variables, and Wilcoxon–Mann–Whitney test for nonparametric variables. The P-value in the final column represents the comparison of each individual SCA (4-group comparison). The final column P-value was calculated with χ2 tests for categorical variables, analysis of variance for continuous variables, and Kruskal–Wallis for nonparametric variables.
SARA, Scale for Assessment and Rating of Ataxia; SCA, spinocerebellar ataxia; UHDRS, Unified Huntington Disease Rating Scale.