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. Author manuscript; available in PMC: 2015 Dec 10.
Published in final edited form as: Biochemistry. 2015 Jun 12;54(25):3871–3879. doi: 10.1021/bi5014485

Figure 6.

Figure 6

Model for human Fe–S cluster biosynthesis and cluster conversion reactions. (A) Synthesis of the [2Fe-2S] cluster intermediate on the SDUF complex. (B) Generation of [2Fe-2S]-ISCU2 species. (C) Ligand exchange reaction to generate [2Fe-2S]-DTT species. (D) DTT-mediated [2Fe-2S] to [4Fe-4S] cluster conversion. (E) Ligand substitution reaction with [2Fe-2S]-SDUF to form [2Fe-2S]-DTT species. (F) Cluster transfer to generate holo-FDX1. Protein complexes are colored red and iron-containing species blue. Reagents necessary for conversion chemistry are shown with arrows.