Skip to main content
. 2015 Nov 19;4(12):1425–1435. doi: 10.5966/sctm.2015-0032

Figure 2.

Figure 2.

BMSC transplantation attenuated ISO-induced cardiac structure remodeling in vivo. (A): BMSC transplantation prevents ISO-induced enlargement of heart size, increase of the heart/body weight ratios, and enlargement of cell size (at least 10 randomly selected fields in three separate experiments) as revealed by H&E staining of the left ventricular myocardium in rats. (B): BMSC transplantation ameliorates the abnormalities of cardiac structural and impairment of diastolic function in ISO-treated rats. Top: Representative echocardiographic images of showing thickening of left ventricle wall and interventricular septum and enlargement of left ventricular chamber at diastole. Bottom: Averaged data on selected echocardiographic parameters including LVPWd, IVSd, and LVIDd. (C): BMSC transplantation suppresses expression of hypertrophic marker genes ANP, BNP, and β-MHC in rats. The data were obtained from three independent experiments. (D): BMSC transplantation inhibits ISO-induced enlargement of cell size as revealed by H&E staining of the right ventricular myocardium (at least 10 randomly selected fields in three separate experiments). The data were obtained from five rats of each group. ∗, p < .05 versus Ctl; #, p < .05 versus ISO. Abbreviations: BMSC, bone marrow-derived mesenchymal stem cell; Ctl, control; ISO, isoproterenol; H&E, hematoxylin & eosin; IVSd, interventricular septal thickness at diastole; LVIDd, left ventricular internal dimension-diastole; LVPWd, left ventricular posterior wall dimension; β-MHC, β-myosin heavy chain.