Figure 6.

Treatment with human ASCs for ischemia-reperfusion injury. (A): Representative samples of treated inguinal fat pads harvested at 7, 14, and 28 days. PBS-treated samples showed injury-induced atrophy on day 28. The relative sample weight (sample weight/body weight) decreased after injury and reached its nadir on day 14 in each group, followed by weight recovery caused by adipose regeneration. The sample weights on day 28 were significantly greater in the spheroid-treated group compared with the other groups. ∗, p < .05. (B): Tissue recovery score was calculated by multiplying the relative weight and the viable area ratio of samples to show the gross recovery of damaged adipose tissue (100% means complete recovery to the level before injury). Nearly full recovery was seen in spheroid-treated samples, which was significantly superior to the other two groups. ∗, p < .05. Abbreviations: ASC, adipose-derived stem/stromal cell; d, days; PBS, phosphate-buffered saline.