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. 2015 Dec 10;10(12):e0144462. doi: 10.1371/journal.pone.0144462

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© 2015 Tsai et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Cellular migration was determined using scratch wound assay and analyzed using the Wimasis WimScratch software. The migratory ability of A549 cells was significantly inhibited by increasing curcumin dosage compared with the control group (p < 0.05). (B) Invasiveness was determined by Matrigel-coated Boyden chamber assay. Curcumin significantly decreased the invasive ability of A549 cells (p < 0.05) when the curcumin concentration was >25 uM. (C–D) The application of recombinant adiponectin (rADN) significantly increased the migratory and invasive ability of A549 cells (p < 0.05). The results of three independent experiments are shown; the assays were conducted in triplicate.