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. 2015 Dec 10;11(12):e1004662. doi: 10.1371/journal.pcbi.1004662

Fig 1. States and dynamics in the TGP model.

Fig 1

A. The initial state of the TGP model is all-cells-wild-type. Type-I cells (black cells) can arise due to type-I mutations. If the number of type-I cells reaches at least the critical tumor size N, a PA-I tumor developed which cannot regress anymore (black box). We assume that a PA-II tumor occurs as soon as the first type-II cell appears in the system (red box). Solid arrows indicate a single transition whereas dotted arrows indicate several transitions. B. Wild-type cells mutate to type-I cells with probability u and type-I cells mutate to type-II cells with probability v during proliferation. Cell death and proliferation are included as follows. A cell is randomly chosen for cell death and replaced by the offspring of another randomly chosen cell. Spatial aspects are neglected in the model.