Fig 6. Inhibition of OCT1 activity by various BIM-related molecules.

HEK-OCT1 cells were incubated with 40 μM [¹⁴C]-TEA for 5 min at 37°C in the presence or absence of 50 μM verapamil or of various BIMs, used each at 5 μM. After washing with ice-cold PBS, intracellular accumulation of [¹⁴C]-TEA was determined by scintillation counting. Data are expressed as % of accumulation of TEA found in control cells, set at 100%, and are the means ± SEM of three independent experiments. *, p < 0.05 when compared with untreated cells (ANOVA followed by Dunnett's post-hoc test).