Table 2. baseline Descriptive Statistics by Fluid Management Strategy.
| Characteristic | FACTT Lite (n = 1,124) | FACTT Conservative (n = 503) | FACTT Liberal (n = 497) | p Lite Versus Conservative | p Lite Versus Liberal |
|---|---|---|---|---|---|
| Age (yr) | 51.8 ± 0.5 | 50.1 ± 0.7 | 49.5 ± 0.7 | 0.045 | 0.007 |
|
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| Male (%) | 583 (52) | 263 (52) | 271 (55) | 0.88 | 0.32 |
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| Acute Physiology and Chronic Health Evaluation III score | 91.0 ± 0.8 | 93.1 ± 1.4 | 95.2 ± 1.4 | 0.18 | 0.007 |
|
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| In shock at baseline (% requiring vasopressors) | 550 (49) | 159 (31) | 171 (35) | < 0.001 | < 0.001 |
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| Baseline creatinine (mg/dL) | 1.6 ± 0.04 | 1.3 ± 0.04 | 1.2 ± 0.04 | < 0.001 | 0.002 |
|
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| Central venous pressure (mm Hg) | 11.7 ± 0.2 | 11.9 ± 0.3 | 12.2 ± 0.3 | 0.628 | 0.132 |
|
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| Pao2/Fio2 | 144 ± 2 | 130 ± 3 | 129 ± 3 | 0.0002 | < 0.0001 |
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| Fluid balance (mL) 24 hr prior to randomization | 2,580 ± 95 | 2,655 ± 156 | 2,875 ± 166 | < 0.001 | < 0.001 |
| Primary cause of acute lung injury (%) | < 0.001 | < 0.001 | |||
| Pneumonia | 668 (59) | 231 (46) | 240 (48) | ||
| Sepsis | 184 (16) | 110 (22) | 123 (25) | ||
| Aspiration | 132 (12) | 82 (16) | 67 (13) | ||
| Trauma | 58 (5) | 38 (8) | 36 (7) | ||
| Multiple transfusion | 20 (2) | 7 (1) | 2 (0) | ||
| Other | 62 (6) | 35 (7) | 29 (7) | ||
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| ICU type (%) | 0.001 | < 0.001 | |||
| Medical | 677 (60) | 333 (66) | 330 (66) | ||
| Surgical | 63 (6) | 50 (10) | 50 (10) | ||
| Medical and surgical | 242 (22) | 74 (15) | 68 (14) | ||
| Other | 142 (12) | 46 (9) | 49 (10) | ||
FACTT = Fluid and Catheter Treatment Trial.
Values are reported as mean ± sem or n (%) as appropriate.