Table 4.
Risk of Liver Fibrosis Associated With Alcohol Abuse in the Canadian HIV–Hepatitis C Co-infection Cohort Study, 2003–2014a
| Analytical Approach and Variable |
Odds Ratio | 95% Confidence Interval |
|---|---|---|
| Available-case | ||
| Alcohol abuse | 1.55 | 0.91, 2.38 |
| Age at baselineb | 1.03 | 0.93, 1.19 |
| Baseline ln(APRI) | 7.29 | 4.15, 19.61 |
| Female sex | 1.85 | 0.98, 2.84 |
| Aboriginal ethnicity | 0.64 | 0.21, 1.07 |
| HCV RNA-positive at baseline | 1.42 | 0.86, 4.79 |
| Duration of HCV infectionb | 1.00 | 0.89, 1.25 |
| HBsAg-positive at baseline | 0.99 | 0.00, 1.91 |
| LOCF | ||
| Alcohol abuse | 1.74 | 0.65, 2.77 |
| Age at baselineb | 0.99 | 0.84, 1.18 |
| Baseline ln(APRI) | 6.20 | 1.98, 12.02 |
| Female sex | 1.30 | 0.90, 2.97 |
| Aboriginal ethnicity | 0.86 | 0.33, 1.36 |
| HCV RNA-positive at baseline | 1.56 | 0.73, 2.26 |
| Duration of HCV infectionb | 1.00 | 0.91, 1.16 |
| HBsAg-positive at baseline | 0.88 | 0.00, 1.18 |
| Multiple imputation | ||
| Alcohol abuse | 1.32 | 1.11, 1.69 |
| Age at baselineb | 0.99 | 0.85, 1.09 |
| Baseline ln(APRI) | 4.86 | 3.02, 8.12 |
| Female sex | 1.26 | 0.89, 1.57 |
| Aboriginal ethnicity | 1.02 | 0.63, 1.48 |
| HCV RNA-positive at baseline | 1.12 | 0.94, 2.09 |
| Duration of HCV infectionb | 1.00 | 0.97, 1.09 |
| HBsAg-positive at baseline | 1.15 | 0.68, 2.09 |
Abbreviations: APRI, aspartate aminotransferase:platelet ratio index; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; LOCF, last observation carried forward.
a The hazard ratio is approximated by the odds ratio obtained from a weighted pooled logistic regression.
b Age and duration of HCV infection were scaled so that the coefficient was associated with a change of 5 years.