TABLE 3.
Study |
Outcome: preterm birth |
Cervical length at initial measurement | Cervical length at final measurement | Change in cervical length over time | |||||
---|---|---|---|---|---|---|---|---|---|
Cut-off value, (GA at testing, wks) |
Youden index |
P valuea | Cut-off value, (GA at testing, wks) |
Youden index |
P valuea | Abnormal test result | Youden index |
||
Singleton gestation | |||||||||
Iams,4 1996 | <35 wk | 25 mm (24) | 0.295 | 0.049 | 25 mm (28) | 0.362 | 0.008 | Any decrease in CL | 0.165 |
<35 wk | 25 mm (24) | 0.295 | 0.44 | 25 mm (28) | 0.362 | 0.12 | Shortening of CL ≥6 mm | 0.241 | |
Arabin,48 2006 | <36 wk | Unreported (15–19) | NC | NA | 25 mm (20–24) | 0.080 | 0.66 | Shortening of CL >10 mm | 0.140 |
Dilek,50 2007 | <37 wk | 35.3 mm (16) | 0.200 | 0.02 | 34.3 mm (24) | 0.657 | 0.56 | Shortening of CL ≥6.6 mm | 0.556 |
Twin gestation | |||||||||
Bergelin,45 2003 | <34 wk | Unreported (24) | NC | NA | 25 mm (28) | 0.129 | 0.56 | Shortening of CL ≥20% | 0.314 |
Gibson,46 2004 | <35 wk | 25 mm (18) | 0.128 | 0.87 | 25 mm (28) | 0.042 | 0.43 | Shortening of CL ≥2.5 mm/week | 0.151 |
Arabin,48 2006 | <36 wk | Unreported (15–19) | NC | NA | 20 mm (20–24) | 0.080 | 0.06 | Shortening of CL >10 mm | 0.285 |
Fox,51 2010 | <32 wk | Unreported (18–24) | NC | NA | 25 mm (20–25) | 0.300 | 0.55 | Shortening of CL ≥20% | 0.427 |
<34 wk | Unreported (18–24) | NC | NA | 25 mm (20–25) | 0.250 | 0.90 | Shortening of CL ≥20% | 0.231 | |
Hofmeister,52 2010 |
<32 wk | 5th percentile (18–21) | 0.264 | 0.02 | 5th percentile (22–25) | 0.478 | 0.35 | Shortening of CL >2 mm/week | 0.631 |
<34 wk | 5th percentile (18–21 ) | 0.206 | 0.04 | 5th percentile (22–25) | 0.344 | 0.36 | Shortening of CL >2 mm/week | 0.470 | |
Oh,54 2012 | <32 wk | Unreported (20–24) | NC | NA | 30 mm (24–29) | 0.503 | 0.98 | Shortening of CL ≥13% | 0.507 |
<34 wk | Unreported (20–24) | NC | NA | 30 mm (24–29) | 0.482 | 0.50 | Shortening of CL ≥13% | 0.350 | |
Khalil,55 2013 | <32 wk | Unreported (20–23) | NC | NA | 25 mm (23–28) | 0.367 | 0.28 | Shortening of CL ≥25% | 0.503 |
<34 wk | Unreported (20–23) | NC | NA | 25 mm (23–28) | 0.317 | 0.03 | Shortening of CL ≥25% | 0.510 | |
Levêque,56 2015 | <34 wk | 35 mm (22) | 0.093 | 0.71 | 25 mm (27) | 0.412 | 0.23 | Shortening of CL ≥20% | 0.170 |
CL, cervical length; GA, gestational age; NA, not applicable; NC, not calculable
For the difference with Youden index of change in cervical length over time