Table 1.

Dimethylsulfoxide (DMSO) ocular findings in mammals

Author	Year	Study subject (# humans)	DMSO toxicity or finding
Laudahn et al. [27]	1966	Humans (9521)	No toxicity
Rubin [38]	1967	Guinea pigs	Lenticular changes
Gordon et al. [24]	1968	Humans (108)	No toxicity
Gordon et al. [24]	1968	Canines	Myopic shift
Gordon et al. [24]	1968	Primates	No toxicity
Hill et al. [28]	1975	Humans (65)	No toxicity
Silverman et al. [39]	1983	Rabbits	Lenticular changes and transient retinal toxicity
Rowley et al. [29]	2001	Humans (1)	Lenticular pigmentary changes
Cao et al. [26]	2007	Cell culture	Apoptosis of human lens epithelial cells (HLEC)
Lüke et al. [32]	2010	Rabbits	Reduced vascularity at bleb injection site
Pina et al. [31]	2011	Mice	None
Galvao et al. [30]	2014	Rats	Retinal apoptosis
Kiland et al. [40]	1997	Monkeys	No toxicity