Table 2.

Annual age-specific increased risk of non-fatal and fatal event estimates used to validate the model within the extrapolation period

Event	% annual age-specific increase	Confidence interval (%)	References
Non-fatal MI	5.00	2.50–7.50	[30]
Non-fatal IS	9.10	4.55–13.65	[30]
Non-fatal HS/ICH	5.90	2.95–8.85	[30]
Fatal MI	4.50	2.25–6.75	[30]
Fatal IS	3.10	1.55–4.65	[30]
Fatal HS/ICH	3.10	1.55–4.65	(Assumption based on IS)
OCD	6.80	3.40–10.20	[30]
NCD	5.60	2.80–8.40	[34]

HS hemorrhagic stroke, ICH intracranial hemorrhage, IS ischemic stroke, MI myocardial infarction, NCD non-cardiovascular death, OCD other cardiovascular death