Table 3.
Patient-specific ceftaroline PK parameters versus package insert
| C max (mg/L) | C min (mg/L) | T ½ (h) | V d (L/kg) | AUC0–τ (µg h/mL) | T > MIC (h) | Clearance (L/h) | |
|---|---|---|---|---|---|---|---|
| Burn patient | 27.5 | 1.69 | 1.5 | 0.42 | 87.6 | 8 | 10 |
| Package insert | 21.3 | 2.3–2.9 | 0.31–0.45 | 56.3 | 9.6 |
It should be noted that the AUC0–τ for the burn patient is for 0–8 and 0–12 h per the package insert (i.e., the dosing interval)
AUC area under the curve, C max maximum serum concentration, C min minimum serum concentration, MIC mean inhibitory concentration, T ½ half-life, V d volume of distribution