Table 4.

Adverse events associated with parenteral fosfomycin in 8 comparative trials [10–17]

Adverse event	Fosfomycin N = 664 n (%)	Comparators N = 626 n (%)
Death	32 (5%)	34 (5%)
Acute kidney injury	25 (4%)	28 (4%)
Skin reactions	14 (2%)	17 (3%)
GI disorders	6 (1%)	16 (3%)
Phlebitis	3 (<1%)	0
Eosinophilia	2 (<1%)	2 (<1%)
Abnormal liver tests	6 (1%)	6 (1%)
Leucopeniaa	1 (<1%)	4 (<1%)

^aLeucopenia was defined as a leukocyte count <1G/l on one trial [11] and not defined in another [15]