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. 2015 Nov 3;310(1):E24–E31. doi: 10.1152/ajpendo.00379.2015

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Fig. 2. — [Leu²⁷]IGF-II's effects on fetal weight variation and no. of fetal growth-restricted (FGR) pups in normal mice. Leu²⁷: n = 26 pregnancies, 199 fetuses; vehicle: n = 25, 180 fetuses. A: C57 population distribution curves for individual fetal weights of [Leu²⁷]IGF-II- (solid line) and vehicle-treated mice (dashed line). Treatment halved the number of pups with <5th centile fetal weights from 6.3 to 2.5% (skewness = 1.14 vs. 1.22) and reduced the number of >95th centile animals from 4.7 to 3%. Individual fetal and placental weights showed reduced variation in treated animals (when tested by F-test of equality of variances). B and C: fetal (P = 0.028; B) and placental weights (0.0032; C).