Table 1.
Summary of methods for measuring cell nuclear fractal dimension
| Method | Fractal Dimension | Length Scale of Measurements (μm) | Sample |
|---|---|---|---|
| Neutron scattering (17, 18) | 2.2–3.2 | 0.06–5 | isolated nuclei |
| Hi-C (8) | 2.92 | 0.5–2 | DNA fragments |
| Rheology (21) | 2.2–2.6 | 0.02–2 | living cells |
| a/LCI (22, 23) | 1.6–2.0 | 1–30 | living cells |
| Box counting (23, 49) | 1.6–1.8, 1.2–1.3 | 0.4–10 | fixed and stained cells |
| Textural analysis (20) | 2.8–2.9 | 0.4–3 | fixed cells |
| TEM (50) | 2.6–3.4 | 0.01–0.4 | fixed tissues |
| ISOCT | 2.5–3.6 | 0.03–0.45 | living cells |