Table 1.
Drug | Sensitivity bin | Kinase X inhibited? | Δ score |
---|---|---|---|
1 | 1 | Yes | 20 |
2 | 2 | No | 0 |
3 | 5 | Yes | −10 |
4 | 1 | Yes | 20 |
5 | 3 | No | 0 |
6 | 4 | No | 0 |
Note: If a drug inhibits Kinase X, points are added based on the sensitivity bin of the drug. For example, Drug 1 inhibits kinase X and is in sensitivity bin 1 (highest sensitivity), therefore 20 points are added to the score. Drugs that do not inhibit Kinase X do not affect the score (Drugs 2, 5 and 6). The total Raw score for Kinase X is calculated by summing over all the drugs in the panel.
Raw KAR Score = 20-10 + 20 = 30.