Table 2.

Functional enrichment within gene clusters whose behavior is associated with household air pollution of burning smoky versus smokeless coal

Gene Cluster 1 (lower in smoky versus smokeless, n = 201 genes)
Enrichment Category: KEGG	P value
Axon guidance (HSA04360)	0.016
VEGF signaling pathway (HSA04370)	0.016
Colorectal cancer (HSA05210)	0.027
Valine Leucine and Isoleucine degradation (HSA00280)	0.045
Enrichment Category: GO biological process	P value
Response to heat (GO:0009408)	0.008
Response to temperature stimulus (GO:0009266)	0.016
Regulation of transcription (GO:0045449)	0.018
Regulation of cell cycle (GO:0051726)	0.020
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (GO:0006139)	0.022
Regulation of endocytosis (GO:0030100)	0.029
Gene Cluster 2 (higher in smoky versus smokeless, n = 81 genes)
Enrichment Category: KEGG	P value
Hedgehog signaling pathway (HSA04340)	0.012
Hematopoietic cell lineage (HSA04640)	0.027
Toll-like receptor signaling pathway (HSA04620)	0.035
Cytokine-cytokine receptor interaction (HSA04060)	0.035
Enrichment Category: GO biological process	P value
Glycerophospholipid metabolic process (GO:0006650)	0.014
Cellular amino acid derivative metabolic process (GO:0006575)	0.015
Negative regulation of cell proliferation (GO:0008285)	0.018
Phospholipid metabolic process (GO:0006644)	0.029
Anatomical structure morphogenesis (GO:0009653)	0.043
Positive regulation of cellular protein metabolic process (GO:0032270)	0.044
Positive regulation of protein metabolic process (GO:0051247)	0.047

Within Enrichr, P values were calculated using Fisher’s exact tests under the assumptions of a binomial distribution and independence for probability of any gene belonging to any set.