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. 2015 Dec 11;5:17935. doi: 10.1038/srep17935

Figure 5. Genipin inhibits inflammatory responses to alum and LPS in vivo.

Figure 5

C57BL/6J mice (n = 8 per group) and NLRP3−/− mice (n = 5 per group) were i.p. injected with genipin (2 mg per body weight, i.p.) or DMSO for 1 h, followed by LPS (35 mg/kg of body weight, i.p.) or alum (2 mg per body weight, i.p.) challenge for 6 h. (A,B) IL-1β concentration in the supernatant of peritoneal lavage fluid was determined. (C,D) The number of neutrophils that had migrated into the peritoneal cavities was quantified. **P < 0.01.