Table 1.
Demographic and Alcohol-Drinking History (from 90-Day Timeline Follow-Back Questionnaire) Characterization of the Study Participants
| Placebo | Varenicline | ||||||
|---|---|---|---|---|---|---|---|
| Nonsmoker (n = 6) | Smoker (n = 6) | Total (n = 12) | Nonsmoker (n = 9) | Smoker (n = 8) | Total (n = 17) | Test of Group Differences | |
| N | N | N (%) | N | N | N (%) | Chi-square P-value | |
| Female | 1 | 0 | 1 (8) | 1 | 2 | 3 (18) | 0.62 |
| FHPa | 4 | 2 | 6 (50) | 2 | 2 | 4 (24) | 0.24 |
| Current abuse | 0 | 0 | 0 (0) | 3 | 2 | 5 (29) | 0.06 |
| Current dependence | 1 | 0 | 1 (8) | 2 | 1 | 3 (18) | 0.62 |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | t test P-value | |
| Age (years) | 37.3 (16.6) | 38.5 (11.3) | 37.9 (13.5) | 27.6 (8.1) | 32.3 (10.6) | 29.8 (9.4) | 0.07 |
| Height (cm) | 179.1(11.1) | 175.4 (7.7) | 177.2 (9.3) | 176.5 (3.3) | 174.7 (7.4) | 175.6 (5.5) | 0.95 |
| Weight (kg) | 89.0 (12.2) | 84.2 (11.6) | 86.6 (11.6) | 77.5 (10.2) | 78.0 (10.7) | 77.7 (10.1) | 0.04 |
| Age at first drink | 15.1 (2.8) | 15.4 (6.7) | 15.3 (4.6) | 15.6 (2.7) | 15.9 (1.3) | 15.7 (2.1) | 0.74 |
| Total lifetime drinks | 15,961.8 (13,928) | 53,088.7 (77,424) | 31,431.4 (51,489) | 16,633.2 (16,779) | 24,650.7 (26,777) | 19,934.5 (21,066) | 0.41 |
| AUDITb | 12.5 (4.2) | 14.3 (6.9) | 13.4 (5.5) | 12.2 (3.4) | 16.4 (5.6) | 14.2 (4.9) | 0.93 |
| SRE total scorec | 8.0 (1.1) | 10.7 (1.3) | 9.3 (0.9) | 8.7 (1.4) | 7.5 (1.0) | 8.2 (0.9) | 0.69 |
| Recent drinking history: 90-day timeline followback | |||||||
| Total drinks | 359 (105) | 530 (185) | 444 (169) | 373 (170) | 476 (256) | 418 (211) | 0.97 |
| Drinking days | 66.2 (17.8) | 65.3 (14.7) | 65.8 (15.6) | 59.1 (19.3) | 79.7 (12.1) | 68.1 (19.2) | 0.63 |
| Drinks/ drinking day |
5.7 (2.3) | 8.2 (2.6) | 6.9 (2.7) | 6.7 (3.4) | 5.7 (2.9) | 6.2 (3.1) | 0.84 |
| Heavy drinking days | 34.5 (11.5) | 54.3 (19.7) | 44.4 (18.5) | 34.2 (21.6) | 51.1 (29.7) | 42.2 (26.4) | 0.95 |
| Smoking measures | |||||||
| Cigarettes/ d | 8.2 (4.5) | 7.7 (6.5) | 0.88 | ||||
| FTNDd | 3.5 (2.6) | 3.5 (1.0) | 0.99 | ||||
AUDIT and Fagerström scores are also depicted. Two subjects in the varenicline group and 5 subjects in the placebo group were excluded from analysis due to insufficient data. P-values were calculated based on chi-squared or t tests.
a Family history positive for alcoholism.
b Alcohol Use Disorders Identification Test.
c Self-rating of the effects of alcohol.
b Fagerström test for nicotine dependence.