Table 2.
Levels of Occupancy of acH3 and H3K27me3 at BDNF Gene Promoters
| Gene promoter | BDNF Val/Val | BDNF Met/Met | p -value |
|---|---|---|---|
| acH3 | |||
| pBDNF-1 | 0.430±0.0996 | 0.572±0.1044 | 0.3819 |
| pBDNF-2 | 0.219±0.0252 | 0.339±0.0447 | 0.0799 |
| pBDNF-3 | 0.442±0.0834 | 0.697±0.1766 | 0.2616 |
| pBDNF-4 | 0.491±0.0478 | 0.493±0.0938 | 0.9858 |
| pBDNF-5 | 0.517±0.0668 | 0.673±0.1110 | 0.2948 |
| pBDNF-6 | 0.812±0.0888 | 1.059±0.0698 | 0.0946 |
| pBDNF-7 | 0.874±0.1258 | 1.118±0.1974 | 0.3561 |
| pBDNF-8 | 0.099±0.0249 | 0.1323±0.0313 | 0.4561 |
| H3K27me3 | |||
| pBDNF-1 | 3.250±0.3227 | 3.717±0.3250 | 0.3658 |
| pBDNF-2 | 3.658±0.1721 | 4.487±0.3230 | 0.0861 |
| pBDNF-3 | 3.555±0.4545 | 4.374±0.5488 | 0.3143 |
| pBDNF-4 | 3.196±0.2194 | 3.300±0.4021 | 0.8321 |
| pBDNF-5 | 2.421±0.0428 | 3.156±0.079 | 0.0012* |
| pBDNF-6 | 3.954±0.0832 | 4.543±0.0557 | 0.0042* |
| pBDNF-7 | 2.992±0.1374 | 3.657±0.574 | 0.0851 |
| pBDNF-8 | 1.645±0.1478 | 2.331±0.079 | 0.0150* |
Data are expressed as percentage of input and presented as mean ± standard error of the mean. Student’s t-test. *significant difference.
BDNF, brain-derived neurotrophic factor.