Table 2.
The Results of Meta-Analyses
| N | n | I2 | SMD | 95% CI | P | Subgroup Difference | ||
|---|---|---|---|---|---|---|---|---|
| Percent change of total brain volume per year | Donepezil | 1 | 164 | na | -0.43 | -0.74 to -0.12 | 0.007 | I2=25.9%, P=.26 |
| Galantamine | 1 | 242 | na | -0.13 | -0.39 to 0.12 | 0.30 | ||
| Memantine | 2 | 218 | 0% | -0.12 | -0.39 to 0.15 | 0.38 | ||
| All drugs | 4 | 624 | 4% | -0.21 | -0.37 to -0.04 | 0.01 | ||
| Percent change of hippocampal volume per year | Donepezil | 2 | 404 | 77% | -0.29 | -0.71 to 0.13 | 0.17 | I2=0%, P=.40 |
| Galantamine | 1 | 302 | na | 0.03 | -0.19 to 0.26 | 0.77 | ||
| Memantine | 2 | 218 | 9% | -0.01 | -0.33 to 0.32 | 0.97 | ||
| All drugs | 5 | 924 | 62% | -0.14 | -0.36 to 0.09 | 0.25 | ||
| Percent change of ventricular volume per year | Donepezil | 2 | 338 | 0% | -0.51 | -0.73 to -0.29 | <0.00001 | I2=96.8%, P<.00001 |
| Rivastigmine | 1 | 513 | na | -1.33 | -1.52 to -1.14 | <0.00001 | ||
| All drugs | 3 | 851 | 94% | -0.79 | -1.40 to -0.19 | 0.01 | ||
| Percent change of total brain volume per half year | Memantine | 2 | 257 | 0% | -0.02 | -0.27 to 0.22 | 0.86 | na |
| Percent change of hippocampal volume per half year | Donepezil | 1 | 63 | na | -1.06 | -1.59 to -0.53 | <0.0001 | |
| Memantine | 1 | 29 | na | -0.16 | -0.89 to 0.57 | 0.66 | ||
| All drugs | 2 | 92 | 74% | -0.65 | -1.53 to 0.23 | 0.15 | I2=73.8%, P=.05 |
Abbreviations: CI, confidence interval; na, not applicable; SMD, standardized mean difference.