Table 3.

[³H]5-HT Uptake from Hippocampal Synaptosomes (fmol/mg)

(SEM)
Experiment	Treatment Group
	SS	SM	NS	NM(1)	NM(2)	NM(3)
PND 40-96	1.467	0.296*	1.393	0.308*
(Figure 1A)	(0.061)	(0.061)	(0.101)	(0.055)
PND 61-100	0.547	0.251*	0.611	0.291*
(Figure 1B)	(0.045)	(0.048)	(0.050)	(0.042)
PND 40-61	1.048	0.286*	1.293	0.611*#
(Figure 1C)	(0.097)	(0.057)	(0.145)	(0.079)
PND 40-88/89/96	0.611	0.160*	0.599	0.286*	0.313*	0.336*
(Figure 2A)	(0.026)	(0.024)	(0.041)	(0.063)	(0.065)	(0.047)
PND 89-96	1.455	0.542*	1.528	0.653*
(Figure 2B)	(0.058)	(0.070)	(0.094)	(0.095)

Rats received oral NIC (N) via drinking water or tap water (S) from PND40-96, PND61-100, PND40-61, PND40-88 (NM(3)) 89 (NM(2)), or 96 (NM(1)) or from PND89-96 and either saline (S) or METH (M) injections at doses and ages delineated in Figures 1 and 2 insets and Methods. Hippocampal tissues were harvested 7 d after last METH or saline injection. [³H]5-HT uptake was performed as described in Methods. Data are expressed as mean values ± SEM. *Values significant different from METH-naïve controls (P<.05). #Values significant different from SM.

Abbreviations: M = methamphetamine; N = nicotine; NM = nicotine/methamphetamine; NS = nicotine/saline; PND = postnatal day; SM = tap water/methamphetamine; SS = tap water/saline.