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. 2015 Dec 11;5:17535. doi: 10.1038/srep17535

Figure 3. Treatment of muscles with rAAV:Fst at the time of denervation or tenotomy mitigates the atrophy of tenotomised muscles, but not denervated muscles.

Figure 3

The TA muscles of mice were administered rAAV:Fst or control vector (rAAV:MCS) immediately prior to denervation (A) or tenotomy (B) surgery, and harvested for measurement of mass and other parameters 2 weeks after surgeries. ***Significant main effect for denervation or tenotomy on TA mass (p < 0.001); ###significant main effect for rAAV:Fst on TA mass (p < 0.001). An additional interaction between group and treatment (p < 0.01) existed in (A,B). For (A,B), post-hoc tests revealed a significant difference in both Sham and Den, and Sham and Ten groups, respectively. Representative images of whole sham and denervated TA muscles receiving AAV:Fst and AAV:MCS (C). Representative H&E stained sections of TA muscles examined 2 weeks after administration of rAAV:Fst and rAAV:MCS (D). Changes in protein synthesis (E) and degradation (F) in sham and denervated EDL muscles administered rAAV:Fst and rAAV:MCS are also shown. ***main effect for denervation on protein synthesis and degradation (p < 0.001); ### and #main effect of rAAV:Fst treatment on protein synthesis (p < 0.001) or degradation (p < 0.05). In (E), post-hoc tests revealed a difference in both the Sham and the Den group (p < 0.05). In (F), post-hoc tests revealed a difference in the Sham but not in the Den group (p < 0.05).