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. 2015 Dec 11;5:18124. doi: 10.1038/srep18124

Figure 7. A model for LdNAT1 knockdown on Leptinotarsa larval-pupal metamorphosis.

Figure 7

Knockdown of LdNAT1 results in the deficiency of seven neutral amino acids, i.e., cysteine, histidine, isoleucine, leucine, methionine, phenylalanine and serine. This delays the onset of critical weight and inhibits insulin/TOR signaling. The onset of critical weight and the inhibited insulin/TOR signaling may change the timing of the 20E pulse and JH level in the final instar larvae. Moreover, the reduced insulin/TOR signaling may also decrease 20E and JH signals. Thus, the growth is retarded and the pupation is impaired in the LdNAT1 RNAi hypomorphs.