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. 2015 Dec 11;5:18189. doi: 10.1038/srep18189

Figure 4. Network models delineating complementary coverages of cellular protein networks provided by the three proteomes.

Figure 4

(a) PPAR and ErbB signaling networks representing Complementary Coverage 1, which were mainly defined by the DEPs and DPPs, respectively. Colored nodes, nodes with gray boundary, and V-shaped nodes represent the DEPs, DPPs, and DGPs, respectively. The nodes in the network models were arranged based on the structures of the corresponding KEGG networks. The arrows and inhibition symbols represent the activation and repression information, respectively, obtained from the KEGG networks and gray edges represent PPIs among the nodes obtained from the six databases (Methods). Plasma membrane was denoted as the blue lines. Backgrounds represent functional modules in the KEGG networks. (b) PI3K-AKT signaling network representing Complementary Coverage 2 and 3. (c) Phosphatidylinositol signaling system network representing Complementary Coverage 3. (d) Cellular networks defined by two types of the complementary coverages (Complementary Coverage 1 and 3): lysosome network defined by Groups 1 and 5 and calcium signaling network defined by Groups 2 and 4.