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. Author manuscript; available in PMC: 2015 Dec 11.
Published in final edited form as: Biochemistry. 2010 Aug 3;49(30):6451–6461. doi: 10.1021/bi100769k

Scheme 2.

Scheme 2

Kinetic Scheme for Interactions of the Triple Mutant with AP- and F-Substratesa

aEMut, mutant APE1; S, free DNA substrate; (EMutS), bimolecular encounter complex; (EMutS)′, subsequent state of the mutant APE1-DNA complex.