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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Kidney Int. 2015 Sep 30;88(6):1261–1273. doi: 10.1038/ki.2015.286

Fig. 7. Correlation of transcriptomic and proteomic analyses of Nrf2 activity in the mouse kidney.

Fig. 7

Microarray and iTRAQ analyses were performed on kidney tissue from Nrf2+/+ or Nrf2−/− mice treated with vehicle (DMSO) or CDDO-Me for 24 h. DE; differentially expressed. The relevant tables are indicated in the boxes. From the microarray analysis, 12 genes were shown to be both significantly downregulated in the kidneys of Nrf2−/− mice and significantly upregulated in the kidneys of Nrf2+/+ mice treated with CDDO-Me. From the iTRAQ analysis, 9 of the genes were also shown to be significantly downregulated at the protein level in the kidneys of Nrf2−/− mice (the remaining 3 genes were not detected at the protein level by iTRAQ). These 9 genes/proteins are therefore considered to be most sensitive to genetic inhibition and pharmacological induction of Nrf2 in the mouse kidney.