Table 3.
Clinicopathologic correlation of MMP-9 and TN-C status in 103 pancreatic cancer
MMP-9 | TN-C | fTN-C | MMP-9 + TN-C | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
- | + | P | - | + | P | - | + | P | - | + | P | |
Gender | 0.480 | 0.066 | 0.573 | 0.096 | ||||||||
Male | 29 | 38 | 35 | 32 | 50 | 17 | 43 | 24 | ||||
Female | 13 | 23 | 12 | 24 | 25 | 11 | 17 | 19 | ||||
Age, years | 0.416 | 0.588 | 0.582 | 0.692 | ||||||||
<65 | 32 | 42 | 35 | 39 | 55 | 19 | 44 | 30 | ||||
≥65 | 10 | 19 | 12 | 17 | 20 | 9 | 16 | 13 | ||||
Tumor location | 0.229 | 0.636 | 0.227 | 0.676 | ||||||||
Head | 38 | 50 | 41 | 47 | 66 | 22 | 52 | 36 | ||||
Body/tail | 4 | 11 | 6 | 9 | 9 | 6 | 8 | 7 | ||||
Tumor size, cm | 0.032 | 0.305 | 0.738 | 0.06 | ||||||||
≤2 | 18 | 14 | 17 | 15 | 24 | 8 | 23 | 9 | ||||
>2 | 24 | 47 | 30 | 41 | 51 | 20 | 37 | 34 | ||||
Lymphatic invasion | 0.019 | 0.021 | 0.008 | <0.001 | ||||||||
Negative | 31 | 31 | 34 | 28 | 51 | 11 | 45 | 17 | ||||
Positive | 11 | 30 | 13 | 28 | 24 | 17 | 15 | 26 | ||||
Vascular invasion | 0.049 | 0.024 | 0.015 | 0.003 | ||||||||
Negative | 32 | 35 | 36 | 31 | 54 | 13 | 46 | 21 | ||||
Positive | 10 | 26 | 11 | 25 | 21 | 15 | 14 | 22 | ||||
Hepatic metastases | 0.009 | 0.003 | 0.003 | <0.001 | ||||||||
Negative | 41 | 49 | 46 | 44 | 70 | 20 | 59 | 31 | ||||
Positive | 1 | 12 | 1 | 12 | 5 | 8 | 1 | 12 | ||||
Differentiation | 0.077 | 0.146 | 0.429 | 0.034 | ||||||||
Poor | 7 | 20 | 8 | 19 | 18 | 9 | 10 | 17 | ||||
Moderate | 29 | 38 | 34 | 33 | 49 | 18 | 44 | 23 | ||||
Well | 6 | 3 | 5 | 4 | 8 | 1 | 6 | 3 | ||||
T-factor (UICC) | 0.021 | 0.137 | 0.035 | 0.043 | ||||||||
T1 | 11 | 6 | 12 | 5 | 15 | 2 | 14 | 3 | ||||
T2 | 16 | 15 | 13 | 18 | 25 | 6 | 20 | 11 | ||||
T3 | 14 | 37 | 21 | 30 | 34 | 17 | 25 | 26 | ||||
T4 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | ||||
Stage (UICC) | 0.019 | 0.012 | 0.005 | <0.001 | ||||||||
1A | 7 | 2 | 8 | 1 | 9 | 0 | 9 | 0 | ||||
1B | 12 | 8 | 9 | 11 | 19 | 1 | 15 | 5 | ||||
2A | 10 | 16 | 15 | 11 | 19 | 7 | 19 | 7 | ||||
2B | 10 | 22 | 12 | 20 | 22 | 12 | 14 | 18 | ||||
3 | 1 | 1 | 1 | 1 | 2 | 0 | 1 | 1 | ||||
4 | 2 | 12 | 2 | 12 | 6 | 8 | 2 | 12 |
The bold values indicate P-values less than 0.05, UICC Union for International Cancer Control