Table 1.
Neuroendocrine carcinoma of the extrahepatic bile duct. Review of the literature
| No. | Author | Age | Sex | Histology | Location | Size | Treatment | Prognosis |
|---|---|---|---|---|---|---|---|---|
| 1 | Sabanathan (1988) | 67 | M | Small cell | Bm | 5 cm | Palliative bypass and chemo. | 6 months, alive |
| 2 | Van der Wal (1990) | 55 | M | Small cell + Adenoca. | Bm | 4 cm | Resection | N.A. |
| 3 | Nishihara (1993) | 64 | M | Small cell + Adenoca. | Bh-Bs | 1.9 cm | Resection | 8 months, alive |
| 4 | Yamamoto (1998) | 71 | F | Small cell + Adenoca. | Bh | 6 cm | Resection | 8 months, dead |
| 5 | Kim (2000) | 64 | M | Small cell + Adenoca. | Bm | 3 cm | Resection | 1 month, alive |
| 6 | Miyashita (2001) | 85 | F | Small cell | Bi | 3 cm | Palliative bypass | 5 months, dead |
| 7 | Edakuni (2001) | 82 | F | Small cell + Adenoca. | Bm | 6 cm | Resection | 45 months, alive |
| 8 | Kuraoka (2003) | 75 | M | Small cell | Bi | 4.5 cm | Resection | 5 months, alive |
| 9 | Hazama (2003) | 60 | M | Small cell | CBD | 0.3 cm | NAC and resection | 12 months, dead |
| 10 | Arakura (2003) | 70 | F | Small cell | Bm | 3 cm | Resection and chemo. | 14 months, dead |
| 11 | Park (2004) | 60 | F | Small cell | Bs-Bm | 3 cm | Resection | 5 months, dead |
| 12 | Thomas (2005) | 54 | M | Small cell | Bh-CBD | N.A. | Resection | 6 months, alive |
| 13 | Kaiho (2005) | 66 | F | Small cell + Adenoca. | Bm | 3.5 cm | Resection and chemo. | 8 months, dead |
| 14 | Sato (2006) | 68 | M | Large cell + Adenoca. | Bi | 2 cm | Resection and chemo. | 3 months, dead |
| 15 | Viana Miguel (2006) | 76 | M | Small cell | Bm | N.A. | Resection, chemo. and irraiation | 5 months, alive |
| 16 | Jeon (2006) | 65 | M | Small cell | Bs-Bm | 2 cm | Resection and chemo. | 12 months, dead |
| 17 | Nakai (2008) | 32 | M | Small cell | CBD | N.A. | N.A. | N.A.(autopsy) |
| 18 | Arakura (2008) | 75 | M | Small cell | Bh-Bs | 6.5 cm | Chemo. and irradiation | 10 months, dead |
| 19 | Hosonuma (2008) | 69 | F | Small cell | Bs-Bm | 3 cm | Biliary drainage | 2 months, alive |
| 20 | Okamura (2009) | 62 | M | Small cell | Bm | 3 cm | NAC, resection and irradiation | 20 months, dead |
| 21 | Yamaguchi (2009) | 77 | F | NEC | Bi | N.A. | Resection and chemo. | 27 months, alive |
| 22 | Demoreuil (2009) | 73 | M | Large cell + Adenoca. | Bh-Bs | 3 cm | Resection and chemo. | 12 months, dead |
| 23 | Sasatomi (2013) | 76 | M | Large cell | Bh-Bs | 5 cm | Resection | 21 days, dead |
| 24 | Current report (2014) | 70 | F | Small cell | Bh | 5 cm | Resection and chemo. | 10 months, alive |
NEC neuroendocrine carcinoma, NAC neo adjuvant chemotherapy, Adenoca. adenocarcinoma, CBD common bile duct, Bh hilar bile duct, Bs superior portion of common bile duct, Bm mid portion of bile duct, Bi inferior portion of bile duct, chemo. chemotherapy, N.A. not available, M male, F female