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. 2015 Dec 11;13:379. doi: 10.1186/s12967-015-0743-2

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© Xue et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Negative correlation between HERC5 and CCL20 mRNA and the association of Tregs infiltration in P_Ts of recurrent patients. a Log₂ fold changes HERC5 and CCL20 mRNA between and P_NATs in the patients who experienced tumor recurrence (n = 9) or the patients who did not (n = 12). A Student’s paired t-test between HERC5 and CCL20 log₂ fold change values for the recurrent patients have p = 0.0003 and p = 0.49 for the non-recurrent patients. Negative correlation between HERC5 and CCL20 mRNA is present in the recurrent patients and not observed in the patients who did not recurrent. b Examples of FOXP3 IHC in P_Ts and P_NATs of a recurrent patient and a non-recurrent patient at ×20 magnification (530 × 460 µm in size per field). c FOXP3 IHC scores were calculated using the average numbers of FOXP3 positive stained lymphocytes in10 randomly selected fields at ×20 magnification (530 × 460 µm in size per field) in hepatocellular carcinoma for each sample. FOXP3 IHC score in P_Ts of recurrent patients (n = 9) were significantly higher than that in non-recurrent patients (n = 9) by Welch’s modified t-test (p = 0.05)