Table 3.
Cox Proportional Hazards Models According to Resting CPI for Death, Mortality, and Ventricular Assist Device Placement
| Variable | Hazard Ratio* | 95% Confidence Interval | P-value |
|---|---|---|---|
| Unadjusted | |||
| Age [years] | 1.02 | 1.004 – 1.03 | 0.006 |
| Male | 1.31 | 0.97 – 1.81 | 0.08 |
| PCWP [mm Hg] | 1.05 | 1.03 – 1.06 | <.0001 |
| Fick CI [L/min/m2] | 0.38 | 0.29 – 0.49 | <.0001 |
| PVR [WU] | 1.22 | 1.14 – 1.29 | <.0001 |
| Creatinine [mg/dL] | 1.64 | 1.32 – 2.01 | <.0001 |
| LVEF [%] | 0.97 | 0.95 – 0.98 | <.0001 |
| CPI† | 2.38 | 1.83 – 3.11 | <.0001 |
| Adjusted | |||
| Age [years] | 1.81 | 0.99 – 1.02 | 0.20 |
| Male | 1.32 | 0.91 – 1.97 | 0.14 |
| PCWP [mm Hg] | 1.01 | 0.99 – 1.03 | 0.16 |
| Fick CI [L/min/m2] | 0.69 | 0.45 – 1.04 | 0.08 |
| PVR [WU] | 1.12 | 1.03 – 1.21 | 0.007 |
| Creatinine [md/dL] | 1.51 | 1.12 – 1.98 | 0.007 |
| LVEF [%] | 0.98 | 0.96 – 1.00 | 0.06 |
| CPI† | 1.52 | 1.03 – 2.28 | 0.04 |
| CPI†‡ | 2.84 | 1.17 – 7.30 | 0.02 |
*
Per unit change if continuous
†
CPI ≥ 0.44 vs CPI < 0.44 [W/m2], 241 events
‡
Multivariable adjustment for the previous variables with the addition of BNP in a subset (n=135) with available BNP values.
Abbreviations: CPI: cardiac power index; PCWP: pulmonary capillary wedge pressure; CI: cardiac index; PVR: pulmonary vascular resistance; LVEF: left ventricular ejection fraction; and BNP: B-type natriuretic peptide.