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. 2015 Dec 8;6(6):e01500-15. doi: 10.1128/mBio.01500-15

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Copyright © 2015 Selitsky et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 7 — Model of miRNA regulation of cholesterol synthesis in chronic viral hepatitis and associated liver cancer. Cholesterol synthesis genes that are significantly downregulated in at least one disease state are shown. Each miRNA is significantly upregulated in at least one disease state relative to uninfected controls and is either a predicted miRNA master regulator of gene expression in at least one disease state based on miRHub P value of <0.05 or has a fold change of >5 compared to uninfected controls. See Fig. S2 and S3 for greater detail. HMGCS1, HMG-CoA synthase 1; HMGCR, HMG-CoA reductase; FDPS, farnesyl diphosphate synthase; SQLE, squalene epoxidase; LSS, lanosterol synthase; NSDHL, NAD(P)-dependent steroid dehydrogenase-like; DHCR24, 24-dehydrocholesterol reductase; SC5D, sterol-C5-desaturase; DHCR7, 7-dehydrocholesterol reductase.