TABLE 1 .
Top 10 most significantly enriched pathways by pathway enrichment analysis of chronic viral hepatitis
| Most significantly enriched pathway (P value) using DE genes from the following disease group(s)a: | ||||
|---|---|---|---|---|
| CHB all | CHB only | CHB and CHC overlap | CHC all | CHC only |
| Signaling by Rho family GTPases (3.55E−04) | CD28 signaling in T helper cells (1.05E−04) | Phosphatidylcholine biosynthesis (1.02E−03) | Phosphatidylcholine biosynthesis (1.86E−06) | Interferon signaling (4.68E−07) |
| Natural killer cell signaling (3.63E−04) | Tec kinase signaling (1.7E−04) | Choline biosynthesis (3.72E−03) | Interferon signaling (1.66E−05) | Pathogenesis of multiple sclerosis (4.57E−05) |
| Role of PRRs (4.47E−04) | Signaling by Rho family GTPases (2.00E−04) | Polyamine regulation in colon cell proliferation/cancer (1.05E−02) | Pathogenesis of multiple sclerosis (2.82E−04) | iNOS signaling (4.79E−04) |
| CD28 signaling in T helper cells (7.08E−04) | Natural killer cell signaling (2.09E−04) | Epoxysqualene biosynthesis (1.41E−02) | Choline biosynthesis (9.2E−04) | Phosphatidylcholine biosynthesis (1.41E−03) |
| CXCR4 signaling (9.12E−04) | CTLA4 signaling in cytotoxic T lymphocytes (5.0E−04) | Toll-like receptor signaling (1.58E−02) | Type I diabetes mellitus signaling (1.58E−03) | Type I diabetes mellitus signaling (2.24E−03) |
| Integrin signaling (1.00E−03) | MSP-RON signaling pathway (6.04E−04) | TREM1 signaling (1.62E−02) | iNOS signaling (4.57E03) | Phosphatidylethanolamine biosynthesis (2.34E−03) |
| NF-κB signaling (1.26E−03) | Renin-angiotensin signaling (7.41E−04) | PRPP biosynthesis (2.14E−02) | Phosphatidylethanolamine biosynthesis (7.94E−03) | Prolactin signaling (3.16E−03) |
| Tec kinase signaling (1.35E−03) | PRRs of bacteria and viruses (7.76E−04) | Arsenate detoxification (2.82E−02) | LXR/RXR activation (1.12E−02) | B cell receptor signaling (3.55E−03) |
| Dendritic cell maturation (1.82E−03) | Integrin signaling (8.13E−04) | Tetrahydrofolate (3.47E−02) | Hepatic fibrosis/hepatic stellate cell activation (0.01) | Antigen presentationpathway (3.55E−03) |
| MSP-RON signaling pathway (1.91E−03) | CXCR4 signaling (1.23E−03) | LXR/RXR activation (5.5E−02) | Communication between innate and adaptive immune cells (0.013) | PDGF signaling (3.89E−03) |
a
Top ten most significantly enriched pathways from Ingenuity Pathway Analysis using either all differentially expressed (DE) genes of a disease group (“all”), DE genes of a disease group with no overlap with any other group (“only”), or DE genes shared between two disease groups (“overlap”). Abbreviations: PRRs, pattern recognition receptors; iNOS, inducible nitric oxide synthase; CXCR4, chemokine (C-X-C motif) receptor 4; CTLA4, cytotoxic T lymphocyte-associated protein 4; MSP, macrophage-stimulating protein; TREM1, triggering receptor expressed on myeloid cells 1; PRPP, phosphoribosyl pyrophosphate; PDGF, platelet-derived growth factor.