Figure 1.

Dendritic spine density is increased in the AS mouse model following a single injection of Reelin. (A) Light micrograph images from Golgi-impregnated hippocampal pyramidal neurons from mock treated wild-type mice (WT Mock), mock treated AS mice (AS Mock) and AS mice at 5 days after Reelin injection (AS Reelin). Scale bar: 10 μm. (B) Quantification of hippocampus area CA1 apical dendrites. Spine density of AS Mock mice is significantly reduced compared with WT Mock littermates. Reelin rescues spine density in the AS mice, restoring it to wild-type levels. WT Mock and AS Reelin, n = 10 slices; AS mock control, n = 11 slices; P < 0.05. *P < 0.05 and **P < 0.01.