Table 3. Clinical and Laboratory Features of PMF Patients Divided by IDH Mutational Status.
| PMF | IDH mutant (mean (SD)) | IDH wild-type (mean (SD)) | P value |
|---|---|---|---|
| Number of patients | 5 | 72 | - |
| Age at recording | 64.2 (20) | 60.6 (14.2) | 0.642 |
| Age at diagnosis | 55.4 (20.6) | 56.93 (14.1) | 0.86 |
| Age at sampling | 63.2 (20.1) | 59.3 (14.02) | 0.679 |
| Females (%) | 5 (100%) | 38 (52.8%) | 0.063 |
| Total leukocyte at diagnosis (mm3) | 9.662 (5.725) | 14.892 (13.886) | 0.482 |
| Hb at diagnosis (g/dL) | 10 (1.3) | 10.6 (2.2) | 0.482 |
| HCT at diagnosis (%) | 31.4 (4.87) | 32.1 (7.13) | 0.694 |
| Platelet count at diagnosis (mm3) | 272.760 (267.777) | 444.948 (366.701) | 0.193 |
| LDH at diagnosis (U/L) | 713 (470) | 836 (390) | 0.251 |
| Spleen size at diagnosis (mm) | 179.4 (30.7) | 198.9 (43.7) | 0.325 |
| PMF | IDH mutant, n (%) | IDH wild-type, n (%) | P value |
| Risk factors for cardiovascular diseases | 3 (60%) | 43 (59.7%) | 1 |
| Splenomegaly group | 5 (100%) | 72 (100%) | 0.594 |
| No splenomegaly | 0 | 1 (1.4%) | - |
| Mild splenomegaly | 2 (40%) | 15 (20.8%) | - |
| Massive splenomegaly | 3 (60%) | 56 (77.8%) | - |
| Bleeding | 3 (60%) | 12 (16.7%) | 0.048 |
| Need for red blood cell transfusion | 1 (20%) | 20 (27.8%) | 1 |
| Hydroxyurea | 5 (100%) | 67 (93.1%) | 1 |
| History of splenectomy | 0 | 4 (5.6%) | 1 |
| AHSCT | 0 | 3 (4.2%) | 1 |
| ASA | 1 (20%) | 46 (63.9%) | 0.072 |
| Leukemic transformation | 1 (20%) | 3 (4.2%) | 0.24 |
| Death | 3 (60%) | 11 (15.3%) | 0.039 |
| Thrombosis | 1 (20%) | 10 (13.9%) | 0.548 |
| Thrombosis group | 5 (100%) | 72 (100%) | 0.802 |
| No thrombosis | 4 (80%) | 62 (86.1%) | - |
| Arterial | 1 (20%) | 6 (8.3%) | - |
| Venous | 0 | 3 (4.2%) | - |
| Arterial and venous | 0 | 1 (1.4%) | - |
| JAK2V617F mutation | 3 (60%) | 55 (76.4%) | 0.592 |
| JAK2V617F group | 5 (100%) | 72 (100%) | 0.401 |
| No mutation | 2 (40%) | 17 (23.6%) | - |
| Low allele burden | 3 (60%) | 37 (51.4%) | - |
| High allele burden | 0 | 18 (25%) | - |
| Karyotype | 5 (100%) | 72 (100%) | 0.671 |
| Normal | 5 (100%) | 62 (86.1%) | - |
| Favorable | 0 | 7 (9.7%) | - |
| Unfavorable | 0 | 3 (4.2%) | - |
| DIPSS-plus | 5 (100%) | 72 (100%) | 0.889 |
| Low risk | 1 (20%) | 14 (19.4%) | - |
| Intermediate-1 risk | 2 (40%) | 25 (34.7%) | - |
| Intermediate-2 risk | 2 (40%) | 25 (34.7%) | - |
| High risk | 0 | 8 (11.2%) | - |