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. Author manuscript; available in PMC: 2015 Dec 11.
Published in final edited form as: J Med Chem. 2015 Aug 28;58(17):6909–6927. doi: 10.1021/acs.jmedchem.5b00709

Figure 2.

Figure 2

Effect of NBD-11021 on cell-to-cell transmission of HIV-1. (a) Antiviral activity of NBD compounds in a CD4-dependent CXCR4-tropic HIV-1 cell–cell transmission assay. Ghost X4/R5 cells and H9/HIV-1IIIB cells were cocultured in the presence of escalating concentrations of test compounds. (b) Antiviral activity of NBD compounds in a CD4-dependent CCR5-tropic HIV-1 cell–cell transmission assay. Ghost X4/R5 cells and MOLT-4/HIV-1ADA cells were cocultured in the presence of escalating concentrations of test compounds. The plots represent the percentage of inhibition of p24 in the target cells Ghost X4/R5. Three independent experiments were performed in triplicate, and the graph is representative of one experiment; the values represent the mean ± standard deviation.