All rest strain and stress-echo variables show a clear trend from patients with no significant coronary artery disease through single-, double-, and triple-vessel CAD patients, but WM and GLS are the parameters most often normal in patients with no CAD (high specificity). CAD, coronary artery disease; nsCAD, non-significant coronary artery disease; WM, wall motion; GLS, global longitudinal strain; ESL, early systolic lengthening.