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. 2015 Dec 7;9:6343–6362. doi: 10.2147/DDDT.S79388

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Tan IIA altered the expression profile of cytokine expression in colon tissue harvested from vehicle-, DSS-, siRNA-, siRNA NC-, Tan IIA-, and PCN-treated PXR lacking mice.

Notes: (A) TNFα, (B) IL-6, (C) iNOS, and (D) MCP mRNA expression was assessed by qRT-PCR; Expression was normalized to β-actin; Each bar represents the means ± SD (n=4); ^###P<0.001 versus vehicle-treated group; *P<0.01 versus PXR siRNA-treated group.

Abbreviations: DSS, dextran sodium sulfate; IL-6, interleukin 6; iNOS, inducible nitric oxide synthase; mRNA, messenger RNA; NC, negative control; PCN, pregnenolone 16a-carbonitrile; PXR, pregnane X receptor; qRT-PCR, quantitative reverse transcriptase polymerase chain reaction; SD, standard deviation; siRNA, small interfering RNA; Tan IIA, tanshinone IIA; TNFα, tumor necrosis factor alpha; MCP, monocyte chemoattractant protein.