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. 2015 Dec 7;9:6343–6362. doi: 10.2147/DDDT.S79388

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Clinical assessment of dextran sulfate sodium (DSS)-induced inflammatory bowel disease in vehicle-, Tan IIA-, and PCN-treated mouse model.

Notes: (A) Dosing scheme; (B) Representative hematoxylin and eosin stained colon sections (left 20×, right 40× magnification); areas of severe colon necrosis are marked with arrows; (C) Histology scores, as assessed according to morphological criteria and the proportion of the colon that was affected by the individual changes relative to the total area of the colon section; (D) Changes in body weight after DSS induction of colitis; (E) Diarrhea scores; (F) Bleeding scores; (G) Macroscopic observation of colon length; (H) Colon lengths; DSS-stimulated elevated histology scores, diarrhea, and bleeding while the body weight and colon lengths were significantly reduced by cotreatment with different doses of Tan IIA or 45 mg/kg PCN; the injury has been ameliorated in dose-dependent manner; Each bar represents the means ± SD (n=10). *P<0.01, **P<0.001 versus DSS-treated group. ^#P<0.05, ^##P<0.01, ^###P<0.001 versus vehicle-treated group.

Abbreviations: PCN, pregnenolone 16a-carbonitrile; SD, standard deviation; Tan IIA, tanshinone IIA.

Clinical assessment of dextran sulfate sodium (DSS)-induced inflammatory bowel disease in vehicle-, Tan IIA-, and PCN-treated mouse model.

Notes: (A) Dosing scheme; (B) Representative hematoxylin and eosin stained colon sections (left 20×, right 40× magnification); areas of severe colon necrosis are marked with arrows; (C) Histology scores, as assessed according to morphological criteria and the proportion of the colon that was affected by the individual changes relative to the total area of the colon section; (D) Changes in body weight after DSS induction of colitis; (E) Diarrhea scores; (F) Bleeding scores; (G) Macroscopic observation of colon length; (H) Colon lengths; DSS-stimulated elevated histology scores, diarrhea, and bleeding while the body weight and colon lengths were significantly reduced by cotreatment with different doses of Tan IIA or 45 mg/kg PCN; the injury has been ameliorated in dose-dependent manner; Each bar represents the means ± SD (n=10). *P<0.01, **P<0.001 versus DSS-treated group. ^#P<0.05, ^##P<0.01, ^###P<0.001 versus vehicle-treated group.

Abbreviations: PCN, pregnenolone 16a-carbonitrile; SD, standard deviation; Tan IIA, tanshinone IIA.