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. 2015 Dec 7;9:6343–6362. doi: 10.2147/DDDT.S79388

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© 2015 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Comparison of clinical symptoms of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD) treated with 20 mg/kg Tan IIA or 45 mg/kg PCN in WT and PXR siRNA-treated mouse model.

Notes: (A) Histology scores and (B) changes in body weight after DSS induction of colitis; (C) Diarrhea scores; (D) Bleeding scores; Marked statistical distinction can be found between PXR-silenced mice and WT mice; Mice with silenced PXR expression cotreated with 20 mg/kg Tan IIA or 45 mg/kg PCN could slightly aggravate severity in DSS-induced IBD, and the therapeutic effect was significantly reduced in PXR-silenced mice compared with WT mice; Each bar represents the means ± SD (n=10); ^##P<0.05, ^###P<0.001 versus vehicle-treated group; *P<0.01 represents WT versus PXR siRNA-treated mouse model group.

Abbreviations: PCN, pregnenolone 16a-carbonitrile; PXR, pregnane X receptor; SD, standard deviation; siRNA, small interfering RNA; Tan IIA, tanshinone IIA; WT, wild-type.