Figure 6.

Human C1-inhibitor (C1INH) reduces CD36-dependent parasite sequestration in vivo. A, Parasite-derived luciferase signal as a readout of CD36-dependent sequestration of mature luciferase-expressing Plasmodium berghei strain ANKA in lung and white adipose tissue (WAT). Infected cells were injected intravenously in mice previously (A) or concurrently (B) treated with vehicle or 260 µg/mouse of human C1INH. Parasite-derived luciferase signal was measured 3 hours later in harvested organs after perfusion.