Figure 7.

Human C1-inhibitor (C1INH) protects against experimental cerebral malaria. A, Peripheral parasitemia and survival of mice injected intravenously with Plasmodium berghei strain ANKA on day 0 and treated with vehicle or 260 µg/mouse of human C1INH twice daily during days 3–9 after infection. Cumulative data are means and standard errors of the mean of 3 different experiments. Sample size: 32 mice per group. B, Representative images of hematoxylin-eosin–stained section of brain tissue from naive and infected mice treated with vehicle or human C1INH as described in panel A and harvested on day 7 after infection, after perfusion. Black arrows show brain microvessels obstructed with leukocytes and infected and uninfected red blood cells. Original magnifications ×10 (left) and ×40 (right) are shown.