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. 2015 Dec 11;10(12):e0144541. doi: 10.1371/journal.pone.0144541

Fig 1. Med promotes bone regeneration at the drill hole site in Ovx osteopenic rats.

Fig 1

(A) Representative confocal images (100X) of calcein labeling shown in the drill holes of various groups fifteen days after injury. (B) Quantification of the mean intensity of calcein label. (C) Representative 3-D μCT images from the center of the bony hole in various groups. (D) BV/TV, Tb.Th were decreased in the Ovx in comparison to the sham and treatment with med and PTH significantly increased these parameters over the Ovx group. Compared with the sham, BS/BV was increased in Ovx rat and treatment with med and PTH reduced it. N = 7 rats/group; data expressed as mean ±SEM with 95% confidence interval. Statistical analysis was performed by one way-ANOVA nonparametric method followed by the Newman–Keuls test of significance using Prism version 3.0 software. c P< 0.001 compjared with Sham + vehicle group; b P< 0.01compared with Sham + vehicle group; a P< 0.05compared with Sham + vehicle group; z P< 0.001 compared with Ovx + vehicle group; y P< 0.01 compared with Ovx + vehicle group; x P< 0.05 compared with Ovx + vehicle group; r P< 0.001 compared with Ovx + 0.5mg/kg med group; p P< 0.05 compared with Ovx + 0.5mg/kg med group; l P< 0.001 compared with Ovx + 1.0mg/kg med group; k P< 0.01 compared with Ovx + 1.0mg/kg med group; j P< 0.05 compared with Ovx + 1.0mg/kg med group; o P< 0.001 compared with Ovx + 5.0mg/kg med group; m P< 0.05 compared with Ovx + 5.0mg/kg med group.