Fig 6. Co-expression of ghrelin with insulin, iAPP, and PC1/3 in the islets of beta-cell-specific Pax6 KO mice.

Double immunofluorescence staining of pancreatic cryosections from 2.5 month old mice at 2 weeks after tamoxifen induction. Ghrelin⁺ cells are not detected in the control islets (a-c). In the beta-cell-specific Pax6 KO islets, ghrelin expression is up regulated (d-f) and some of the ghrelin⁺ cells co-express insulin (d). Additionally, these ghrelin⁺ cells co-express iAPP (e) and PC1/3 (f).