Fig 12. Expression of proSAAS and 7B2 in the islets of beta-cell-specific Pax6 KO mice.

Double immunofluorescence staining of pancreatic cryosections from 4 month old mice at 6 weeks after tamoxifen induction. In the control islets, expression of proSAAS and 7B2 is low in the YFP labeled beta-cells (a-d). In beta-cell-specific Pax6 KO islets, expression of both proSAAS and 7B2 is highly up regulated in the YFP⁺ Pax6-deficient cells (e-h).