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. 2015 Dec 11;10(12):e0144597. doi: 10.1371/journal.pone.0144597

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© 2015 Ahmad et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 16 — Double immunofluorescence staining of pancreatic cryosections from 1 month old mice. In control islets, all the YFP⁺ cells express Pax6 and glucagon (a-c). In alpha-cell-specific Pax6 KO islets, most of the YFP⁺ cells are negative for Pax6 and have lost the expression of glucagon as well (d-f). YFP^- glucagon⁺ cells in the KO islets express Pax6 (arrowheads d-f). Rarely YFP⁺ glucagon⁺ Pax6^- cells are also found in the KO islets (arrows d-f). Quantification of YFP⁺ glucagon⁺ cells in relation to total glucagon⁺ cells in 1 month old non-inducible alpha-cell-specific control (Glu-Cre;R26-YFP;Pax6 ^+/+) mice, and in Dox-inducible alpha-cell-specific control (Glu-rtTA;TetO-Cre;R26-YFP;Pax6 ^+/+) mice at 4 months of age following 6 weeks of Doxycycline treatment (g) (n = 3). Nearly 68% and 75% of the glucagon⁺ cells are labeled with YFP in non-inducible and Dox-inducible alpha-cell-specific control mice, respectively. Error bars represent SEM.