Fig 3. FG density plot of Nup145N ring.

The wildtype ring shows a more even and inter-connected network of FG-repeats. On the other hand, FG network formed in the mutated ring is more aggregated to high-density regions with more limited interactions between different copies of Nup145N. This highlights the regulatory effect of like charge regions (LCRs) in effective distribution of FG-repeats inside the NPC. The rings are shown from the top view.